Topical Methotrexate for Treatment of Psoriasis: Formulation and Clinical Implications
نویسنده
چکیده
Background: To test effectiveness and safety of topical methotrexate 0.5%gel and to introduce new formula of methotrexate gel using suitable media for delivery. Patients and Methods: The clinical work was performed at the Department of Dermatology and Venereology in Baghdad Teaching Hospital during the period from January 2008 to October 2008. While preparation of formula was performed in the laboratories of the Department of PharmacologyCollege of Medicine-University of Baghdad. Patients were divided in to two groups according to the type of treatment, group (I) 32 patients treated with methotrexate 0.5% gel and group(II) (placebo group) included 33 patients treated with placebo gel. Results: A total of 65 patients with limited plaque psoriasis were included in this study. For the MTX group the mean PASI score before treatment was 7.07 while at 2, 4, 6 and 8 weeks treatment, it was decreased to 5.17, 3.93, 3.07 and 2.35 respectively. At eight weeks treatment 25(78%) patients
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Topical Methotrexate For Treatment of Psoriasis: Formulation and Clinical Implications Murtadha
Background: To test effectiveness and safety of topical methotrexate 0.5%gel and to introduce new formula of methotrexate gel using suitable media for delivery. Patients and Methods: The clinical work was performed at the Department of Dermatology and Venereology in Baghdad Teaching Hospital during the period from January 2008 to October 2008. While preparation of formula was performed in the l...
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Psoriasis is an autoimmune and recurrent chronic inflammatory skin disease. About 1-3% of the world wide populations are affected. The characteristic features are hyperprolifration of keratinocytes leading to redness, thickening and scaling of epidermis followed with itching and appearance of the lesions which in most cases bother the patients medically and psychologically. Psoriasis is symptom...
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